Buildout and integration of an automated high-throughput CLIA laboratory for SARS-CoV-2 testing on a large urban campus.

In 2019, the first cases of SARS-CoV-2 were detected in Wuhan, China, and by early 2020 the first cases were identified in the United States. SARS-CoV-2 infections increased in the US causing many states to implement stay-at-home orders and additional safety precautions to mitigate potential outbreaks. As policies changed throughout the pandemic and restrictions lifted, there was an increase in demand for COVID-19 testing which was costly, difficult to obtain, or had long turn-around times. Some academic institutions, including Boston University (BU), created an on-campus COVID-19 screening protocol as part of a plan for the safe return of students, faculty, and staff to campus with the option for in-person classes. At BU, we put together an automated high-throughput clinical testing laboratory with the capacity to run 45,000 individual tests weekly by Fall of 2020, with a purpose-built clinical testing laboratory, a multiplexed reverse transcription PCR (RT-qPCR) test, robotic instrumentation, and trained staff. There were many challenges including supply chain issues for personal protective equipment and testing materials in addition to equipment that were in high demand. The BU Clinical Testing Laboratory (CTL) was operational at the start of Fall 2020 and performed over 1 million SARS-CoV-2 PCR tests during the 2020-2021 academic year.

Development of at-home sample collection logistics for large-scale seroprevalence studies.

BACKGROUND: Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. METHODS: We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations. RESULTS: This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study. CONCLUSIONS: High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys.

Supporting Medical Student Mental Health during COVID-19: Strategies Implemented for an Accelerated Curriculum Medical Campus.

Medical student education has not been immune to life altering changes of the global Coronavirus disease 2019 (COVID-19) pandemic. Pre-pandemic anxiety and mental health concerns were already a significant problem in the world of medical student education. Educators are reformulating strategies to address the increased demand for mental health services and wellness during COVID-19. Adaptations include increased and varied internal and student focused communication, as well as new support structures built around student connection and coaching, mental illness, and general wellness. Additional alterations to student support include expanded mental health counseling and also incorporating novel wellness events in an effort to support thriving during COVID-19.

DairyCare 'blueprint for action': husbandry for wellbeing.

'Keep calm and carry on' was a wartime message to the British public that has achieved renewed fame in the last few years. The strategy was simple: in times of extreme difficulty a cool head combined with stoicism is an appropriate response to ensure a successful outcome. The latest major challenge to society (COVID-19) met with a very different response, and only history will reveal whether 'Stay home and worry' will be equally effective. In devising blueprints or strategies it is extremely important to have a clear idea of what you are trying to achieve, whether it be maintaining world freedom or stopping a pandemic. In the case of livestock agriculture, it is helping to feed a rapidly growing global population in harmony with the needs of current and future generations. I hope that I have stated this clearly, and calmly. If so, I ask you to picture a scene. We are on a Calm Farm. Dairy animals go about their daily lives contented, unhurried and focused on the simple feeding and socialising activities that are so important to them. Unstressed, their productive capacities and abilities to avoid and, when necessary, cope with physiological and pathological challenges are maximised. They are not alone: the exact same characteristics also apply to the farmer and husbandry staff that we meet. How is this calm farming approach relevant to the aspirations we had when we established the EU COST Action DairyCare? Our objective was to harness the power of computing technologies to assist our management of dairy livestock. A simple rearrangement leads us to Computing Assisted Livestock Management, CALM. In this short Research Reflection I shall assess how far we have come towards the achievement of sensible goals related to technological assessment of dairy animal wellbeing, and speculate on what more things both can and need to be done to finish the job. It is a personal account. DairyCare was a major collaboration involving several hundred active researchers. To involve them all would be impossible, and I do not pretend to speak for them all. As will become evident, the wide skills base that was assembled was so successful in its primary objectives that different skills, chiefly in economics, are now needed to exploit all of the technological advance that has been achieved. DairyCare succeeded in a second direction. Whilst the focus was technology development, by assembling a large cohort of biologists with animal welfare interests, it soon became apparent that technology should run alongside and help to enable improved management practices. This Special Issue is, therefore, in two sections. The first is dedicated to technology development and the second to a novel management practice that has the potential to significantly improve the wellbeing of cows and calves: cow-calf contact rearing. That section is introduced by my DairyCare colleague, Sigrid Agenäs.